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 Wysłany: Pią 19:56, 18 Mar 2011 Temat postu: 补硒与锌对 |
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补硒与锌对梭曼中毒大鼠乙酰胆碱酯酶活力和抗氧化力的影响
iemeolori~tricassay0fcll0lil妊船raseactiJ]．Bu／／M／／Med(军事医学科学院院刊)，1986，10(3)：211—214．【6JJiJP，WuZB，IiuQ6，YS，YeM，Li砌．Anlll一曲Ⅲicm舡Ialyticandrapid瞅ll0dfor如mion0f~per-oxide出砌Ⅱase枷嘶[J]．．，舭l，岫MedCo／／(南京铁道医学院学报)，1991，l0(1)：27—30．【7JBredtDS，SH．onofnitricoxidesy1，acaImre溅enI-e[J]．ProeⅣ(1tfUSA，1990，s7(2)：682—685．·l2O·EffectofSeandZnonacetylcholinesteraseandantioxidativecapacityinsomanpoisonedratsYANGXing-Bin，YANGHui．Xuan，JIANGN，ZHAOYah2，GUXiao-G~g，HAIChun-Xu(1．DepartmentofTox／co／ogy，2．p口ofChem／stry，theFourthMed／ca／，X／饥710032，Ch／na)Abstract：AIMTostudythefeas~ofpre—ventionfromsomanintoxicationbyantioxidantsSeandZn．Ⅱ1【j[0Fortymaleratswereran—domlydividedinto4groups：controlgroup，SO-mangroup，Segroup，andZngroup．Ratsincon-trolandsomangroupswereoIaUyadministratedwith5mL·kg-1physiologicalsalineperdayf0r9d．RatsinSegroupreceived1mg‘kgNaESeO3andratsinZnonereceived4mg。kg一zincglu-conate．Exceptcontrolgroup，ratsweregivenscO．9LDs08onlallonthe10thday．After2h，theratsweresacrificed．Acetylcholinesterase(AQlE)ofwholebloodandsuperoxidedismutase(SOD)，nitricoxidesynthase(NOS)activityandtotalan—tioxidativecapacity(T-AOC)of8onlallpoisonedratserum．cel~blMnlandliverweredeterminedrespectively．REqULTSAChE，SODactivityandT-AOCofratsdecreasedandNOSactivityin—ceasedat2haftersc8omsn．PretreatmentofSeandZnreducedthed眦mesinAChE，SOD，NOSac、rit、randT-AOCinducedby$oman．CON-CLUSIONSeandZnhavepreventiveeffectagainstsoInanintoxicationinrats．Keywords：soman；selenium；zinc；aeetyl-cholinesterase；antioxidativecapacity(本文编辑乔虹)
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