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helikopter
Dołączył: 03 Mar 2011
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Skąd: England
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 Wysłany: Śro 4:30, 16 Mar 2011 Temat postu: UGG stivali ywc nkd iqy iyb |
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,[link widoczny dla zalogowanych]
Children react to the characteristics of the drug
Physicochemical properties, the main body of the composition. With the development of children, their body composition are different at different developmental stages,[link widoczny dla zalogowanych], and this will inevitably affect the distribution of drugs. Such as water in a mature weight of newborns about 7O ~ 75. The adults only 50 ~ 6O, the proportion of immature newborn water up to 85. Extracellular fluid in the newborn is about 40, from man-2O. This will definitely affect the drug concentration when the destination site. Thus affecting the effect of the drug. Premature infants less fat than the term to children, the former accounting for about fat weight 1, which is about l5. Therefore, the fat-soluble drugs premature to children is clearly volume is less than full-term children to affect the plasma protein content and distribution of drug delivery is another important factor tangled. In the newborn. Drug and plasma protein binding rate. Compared to children to term. Children with the same amount of drug absorbed by the larger proportion of free drug concentration. Such as local anesthetic, diazepam, phenytoin, phenobarbital, etc. Anbianqingmei orderly and drug free drug concentration in the newborn can be significantly increased, and thus easily lead to the poisoning of certain drugs can compete with the serum bilirubin tangled white protein and with the combination. If the drugs given to newborn jaundice, bilirubin is not only can replace the tangled protein and drugs combined, and a large number of free bilirubin can enter the brain through the blood-brain barrier neonatal tissue Erzhi nuclear yellow pox. Visible. Because of different body composition, the distribution of drugs in the body significantly different. At the same time. The slow elimination process must lead to an increase in the accumulation of drug in the body or even poisoning. The newborn, to children medication dosage conversion to rely solely on body weight and sometimes it is not appropriate. After the birth of the body in children during development. Elimination capacity of drugs may be changing rapidly. Therefore, certain drugs to the newborn, to children monitored during treatment to ensure the efficacy of plasma concentrations of the necessary measures to avoid side effects. At the same time d,[link widoczny dla zalogowanych], JL metabolism and function of holding the development of non-barrier discharge first reflected in the disposal of the drug. The clinical use of plasma drug concentration is usually less bad situation, drugs and their metabolites in urine excretion and dirty mixed function oxidase system activity, can be analyzed newborns, to children of drug into the ability of the body. 3. To young children, especially between the sick child of the question, individual differences in drug response is high. The role of the nature of many drugs. And between the d'JL d'JL are similar between adults. However, the actual effect of drug is a big difference. But there are also down outside. To apply the Fourth Ring palm and child care can affect the growth hormone, tetracycline stained teeth from the index, aspirin, I bow from the liver damage and metabolic acidosis, and no adult use of these drugs do not poison the reaction. Fork, such as the role of digoxin in neonates, children and the children to not only the amount of difference, even a qualitative change in children at different developmental stages. Digoxin dosage range may be wider, such as the newborn is 7.5 ~ 12.5/kg. Compared to children l5 ~ 20 ~ g / kg. Older children about lO ~ 15g/kg. Ken obviously, compared with the children, newborns and children may need to be more digoxin to get the corresponding plasma concentrations. Fork, as some children can tolerate higher doses of digoxin without toxicity, which may be related to the individual distribution of the drug product and eliminate the pit. However. Children should not rule out myocardial sensitivity to digoxin, and the corresponding enzyme activities of different. Proved. In to children. Serum digoxin concentrations are often only appear on more than 3ng/ml toxic reactions, such as children and adults may be toxic when over 2ng/ml. Growth and development of the ship in 4xJL stage. And the corresponding neurotransmitter receptors are different from adults. For example, to young children. Neurotransmitters may be due to variable storage mechanism being imperfect, in order to increase blood pressure. Often require more norepinephrine tangled. In addition to halothane sensitivity of newborn myocardium has increased 4. In pathological conditions,[link widoczny dla zalogowanych], various features are easy to care less. Adults similar to this point. Only the degree of decrease greater than adults. Therefore, medication should be cautious at this time. In short, at different times after birth, children of different ages medication. Must take into account possible different responses from adults. Differences in these reactions, which may arise from genetic defects in children,[link widoczny dla zalogowanych], may come from various tissues and organs of children with physiological and biochemical aspects of the development is not base. Children may also come from specific disease state. These reactions may include quantitative and qualitative differences. Therefore, the clinical use of drugs must be careful, patients should be closely observed after treatment of children with reactions. Just in case. Parents consider giving their baby medication. Must consider the full, always in close coordination with the doctor. Make your own baby grow up healthy. (Should be just) 59
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