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Dołączył: 03 Mar 2011
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 Wysłany: Czw 4:25, 17 Mar 2011 Temat postu: tn requin pas cher htd dks oyq wqv |
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Both verapamil sustained release tablets in normal volunteers, the pharmacokinetics and pharmacodynamics of
/ F two kinds of verapamil sustained release tablets in normal volunteers, the pharmacokinetics and pharmacodynamics of Huang Yi-Gui Lan Tian Runxia erected chloroquine (Cardiovascular Research Center of Nanjing Railway Medical College, Nanjing 210009, China) 1 Materials and methods both verapamil hydrochloride sustained release tablets, respectively, and Germany by the Nanjing Institute of Materia Medica Pina Knoll Pharmaceutical Company. Volume 7 healthy male volunteers. Randomized crossover design,[link widoczny dla zalogowanych], the interval between the two drugs medication, asked more than in 1wk. 240mg verapamil in the morning 7 Dayton eyes, the same as two tablets. Before taking the drug, and ophthalmic blood pressure pulse after the 1,2.3,4,5,6,8.12,[link widoczny dla zalogowanych],16 t24h record I lead ECG, liver tangled with police from the elbow of static pay attention anticoagulant blood plasma concentration of rinse. Analysis by HPLC and determination of plasma concentrations of verapamil. Rinse volume of ECG P wave width and height, PR interval,[link widoczny dla zalogowanych], ORS wave duration, QT and T wave height of asking. To the electrocardiogram, blood pressure, heart rate and blood drug concentration for linear correlation and regression analysis. The two groups before and after treatment of blood pressure, the worry over the same period changes in PR paired f test with their own. Pharmacokinetic parameters of drug pharmacokinetics and biological Pina enucleation procedure PRBP-N pry school computer package count. 2 Results LYG tablets (Lianyungang Pharmaceutical Factory production) In addition to plasma drug concentration (c ~) less than the Knoll chip, break when the bee left early, half-life and mean residence time with the sun channel (MRT) is longer, more drug moment curve for the smooth, short drug area under the curve between the two (AUC) was similar. The two drugs before and after treatment with a high degree of ECG P wave duration, QRS wave duration, QT and T wave amplitude question of no change over the same period can be extended to the PR. Knoll film is more obvious than LYG film,[link widoczny dla zalogowanych], the former maximum extension of time for the o. 463. The latter is 0.36s. Changes in the PR period (△ PR) and blood drug concentration for linear correlation and regression analysis, LYG tablets and Knoll pieces correlation coefficients were 0.924.0.81, test of significance by a linear relationship between the two drugs have slightly lower diastolic blood pressure effect, Knou film ranges from the biggest buck 0.79kPa, LYG film received your samples to 0.74 for a 10-23 foot 77zkPa. Both have a mild effect of slowing the heart rate, lowered by 8. Serum concentration of two drugs with blood pressure, heart rate not related off screen. Knoll pieces 4 people had transient palpitation, chest distress, the symptoms occurred in the drug and after 6 ~ 8h {T ~ similar, LYG 2 appeared flustered chest film, the c ~ higher than the others. 3 Discussion verapamil pharmacokinetics of sustained-release tablets are still no reported. This paper reports the country Knoll company Lianyungang kind of verapamil sustained release tablets in normal volunteers in the Velvet pharmacokinetics and pharmacodynamics. The results showed that: two tablets with the pharmacokinetic absorption process is slow. Longer half-life. Flat curve characteristics such as drug pm q:. LYG film except Cmax less than Knoll pieces, both AUC similar. Two sustained-release tablets of normal blood pressure,[link widoczny dla zalogowanych], no mind, but could significantly prolong the PR and Q and blood drug concentration on a linear relationship. In addition. This study also suggests a level c drug delete response. This study provides two refuse verapamil sustained-release tablets from different areas of some pharmacokinetic parameters for clinicians to provide a theoretical basis for rational drug use.
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