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 Wysłany: Nie 9:19, 06 Mar 2011 Temat postu: 胃癌组织rasĄ |
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胃癌组织ras族基因突变与预后的关系
enePointE51I)engGR，eta1．Correlationofmutationsofoncogenec—Ha—rasatcodon12withmetastasisandsurvivalofgastriccancerpatients．OncogeneRes，1991，6：33．ECBarbacidM，eta1．Rasgene．AnnRevBiochem，1987，56：779．E7]MariyamaM，eta1．Frequencyandtypesofpointmu—tationatthe12thcodonoftheK—rasgenefoundinpancreaticcancerformJapanesepatients．JpnJCan—cerRe5，1989，80：622．[8]NanusDM，eta1．Infrequentpointmutationofrasoncogenesingastriccancers．Gastroenterology，1990，98：955．[9]Kinhana．T，a1．Pointmutationofc—Ki—rssoncogeneinadenomaandadenocarcinomawithtubulardifferen—tiation．nJCancerRes，1991，82；308．[1o]HillSA．Clonalheterogeneity，experimentalmetastat—icabilityandp21expressioninH—rastransformedNIH3T3cells．JNatlCancerInst．1988．80：484．MutationinGastricCancerFangDian—chun，LuoYuan—hui，LuRong，eta1．(DepartmentofGastroenterology，SouthwestHospital，ThirdMilttaryMedicalCollege，Chongqing，630038)AbstractPolymerasechainreactionandrestrictionfragmentlengthpolymorphisms(PCR—RFLP)analysiswasusedtodeterminethepointmutationsatcodon12and61ofthec—Ha—ras，atcodon12and13ofK—rasandatcodon12ofN—rasgenesin88formalin—fixedparafin—embeddedgastriccancertissues．Theresultsshowedthatthetotalrateofraspointmutationwas18．2，andthatthepositivityofraspointmutationwasrelatedtotheserosalinvasion，thestatusoflymphnodemetastasis，diseasestageandpostsurgicalsurvivalperiod．Ourresultssuggestedthatthedeterminationofrasgenepointmutationingastriccancertis—susemaybeusefulinpredictingprognosisofpatientswithgastriccancer．KeywordsgastriccancerraspointmutationPCR～RFLP
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