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Dołączył: 03 Mar 2011
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 Wysłany: Sob 4:47, 26 Mar 2011 Temat postu: Diffuse large B cell lymphoma clinicopathologic an |
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Diffuse large B cell lymphoma Clinical and Pathological Analysis
0 and Pan. B to identify . ② hyperplasia infectious mononucleosis (IM), IM, because there have been massive in the activated lymphocytes , easily confused with DLBCL , and the activation of CD30 -positive cells , immunohistochemistry seems to help much . But Alexandra methods available to confirm clinical immunology , and sometimes follow-up is necessary. CD30 staining in the IM when heterogeneity , that is, the intensity of CD30 expression is different , and in the case of lymphoma , immunohistochemistry showed homogeneity. However, younger patients in the diagnosis of DLBCL , we should take into account the possibility of IM . In addition, the coral structure is not completely destroyed lymph nodes , sinus cable structures can be seen clearly . Large cell atypia were not evident. ③ necrotizing lymphadenitis , necrotizing lymphadenitis in necrosis can also be found on the basis of a large number of activated cells, lymphocytes and sometimes even visible capsule invasion , but the debris this time necrosis was seen in the necrotic area around the obvious visible Cell responses. Necrosis around the DLBCL cells but not a significant response. ④ Burkitt lymphoma (Burkittlymphoma, BL),[link widoczny dla zalogowanych], BL phenomenon can be seen clearly in the sky , but not DLBCL cell volume larger than a single cell morphology and mitotic extremely high. In the last category that the BL of cells derived from germinal center of a small non-cleaved cells. Although both are highly malignant lymphoma , but the treatment is different , so the distinction between pathological or necessary. In the new WHO classification , DLBCL include the following three subtypes : mediastinal large B cell lymphoma , intravascular large B cell lymphoma and primary effusion lymphoma. Histological subtypes of the mother can be a central cell, the immune cells of the mother , the mother cell plasma , lymphomatoid granulomatosis , full of T or B cells in DLBCL and anaplastic large cell lymphoma. The purpose of a variety of histological types is to enable a better understanding of the pathologist DL-BCL, but the difference in the outcome was no significant difference. 【
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