MBT outlet,Further study the effectiveness of lept

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Further study the effectiveness of leptin

Key words: leptin (Leptin) recent diabetes obesity insulin, leptin (Leptin) the so-called anti-obesity hormone,[link widoczny dla zalogowanych], by the attention. The focus Ⅰ and Ⅱ clinical trial results, these results indicate that a reorganization of two methyl sulfide (eggs, GT, methionyl) Human leptin has an acceptable safety performance characteristics and causes dose-dependent weight reduction. Creenberg Tufts University School of Medicine explained that the reason why the result is a kind of exciting is that leptin has been shown to be in control of the body has a role in the natural human protein. Who participated in the study of obesity maximum daily dose of leptin injections, the average weight after 6 months dropped nearly 16 pounds. Randomized dose and placebo in multi-center study, 53 lean subjects were moderately obese and 70 randomly assigned subjects received daily 4 doses of leptin or placebo group 1 species the subcutaneous injection, continued for a month (a two sulfonyl recombinant human leptin, a synthetic form of natural human hormones, it is the adoption of leptin by the Amegan generated DNA). Range from a daily dose of 0.01 mg / kg per day to 0.30 mg / kg. Obese participants body mass index (weight in kg divided by height in meters measure the value of the number of square number) at least 27.5 kg / sq m,[link widoczny dla zalogowanych], which is a known to develop other diseases such as diabetes and heart disease risk in overweight level. In addition, all personnel participating in the study reduced body weight and eating a special diet,[link widoczny dla zalogowanych], based on age, weight and activity level, the individual has been specially formulated diet to provide the basis for each person less than 500 kcal of energy demand heat. Recipes using self-report compliance monitoring mechanism. Researchers in the first month of the end of all participants in the research trials found a statistically significant dose - response relationship between weight loss, this time, the average weight range: the average weight loss in patients receiving placebo 0.4 kg (0.91b); received the highest dose of leptin in patients with an average weight loss 1.9 kg (4.21b). 60 obese patients who continued to participate in other items for a period of 5 months of testing, 76% of the patients completed the entire study. After 6 months the average weight range: those taking the lowest dose of leptin in patients with an average weight loss 0.7 kg (1.51b), while patients receiving the highest dose of leptin in weight loss of nearly 7.2 kg (161b). Indexes of blood and liver,[link widoczny dla zalogowanych], renal function, electrocardiogram (ECG) and physical examination and laboratory monitoring shows that leptin does not cause significant side effects. The most common side effects are mild injection site skin reactions (redness, itching or swelling). Not everyone Although weight loss in the design of this study is not intended to confirm the efficacy of leptin, but provides limited useful information about leptin. Some patients in all dose levels can reduce body weight; However, not every person can be exposed to leptin in weight loss. Higher doses of leptin resistance in some patients can produce antibodies may be a problem, although leptin has not been neutral, but show no clinical significance. Amegan company has already developed a kind of first-generation leptin molecule, expect the product to promote high levels of protein release. The first phase of the form leptin pharmacokinetic trial has recently started. In the latest round of cycle, not every protein in patients taking the weight loss can make the fact that researchers have been baffled and upset. Greeberg said that he did not expect to play a role of leptin on everyone, because obesity is a complex, multifactorial disease. Although the small study, the results are preliminary,[link widoczny dla zalogowanych], but he remained cautious optimism. Once the ongoing large-scale clinical studies confirmed the ability of leptin can reduce body weight, that will help treat those with type 2 diabetes are overweight. Complex links with the diabetes expert attention diabetes characteristics of leptin in reducing body weight, because obesity is to prevent the effective treatment and control of the main factors for type 2 diabetes. The forms of the disease with people who, more than 5% weight loss can improve the body's sensitivity to insulin. Most common weight control methods (such as diet and physical exercise and drug channels) can produce a short-term success of effect, but the ultimate goal of maintaining weight loss was still difficult to achieve. Generally speaking, weight loss drugs is fed through the changes and the activity of the neurotransmitter, increasing the energy consumption of certain adipose tissue and reduce the absorption of the gastrointestinal tract and reduce the amount of lipid intake. While obesity can be simply interpreted as a kind of physical energy consumption and the imbalance between consumption, but its etiology is complex, these factors are involved, including genetics and metabolism, similar to the a neurological condition (eg, satiety, and individual behavior and cultural factors) and the environment. The genetic basis of human obesity is not clear, although many genes involved in regulating metabolism and appetite.

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