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 Wysłany: Czw 10:06, 24 Mar 2011 Temat postu: beats devil Can Genetic Information Be Controlled |
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Can Genetic Information Be Controlled By Lasers?
DNA, the molecule that acts as the conveyor of genetic information in always fashions of life, is highly resistant against correction by ultraviolet laser, but knowing the machinery for its photostability presents some ambiguous problems. A key facet is the interaction between the 4 chemical bases that make up the DNA molecule. Researchers at Kiel University have succeeded in showing that DNA strands diverge in their laser sensitivity relying on their base sequences.
It has been understood because numerous years that the individual bases that code the genetic message included in DNA show a high degree of photostability, as the stamina that they comesintoseffect from UV radiation namely quickly released anew. Surprisingly, although, it is found that in DNA, which consists of many bases, those mechanisms are ineffective alternatively only partially telling. It seems that the deactivation of UV-excited DNA molecules have to instead happen along some entirely different mechanisms characteristic to DNA,[link widoczny dla zalogowanych], which are at present understood. Through dimensions by a variety of means on DNA molecules with different base sequences, the research group led by Professor Friedrich Temps at the Institute of Physical Chemistry of Kiel University has now been skillful to confirm and specify that speculation.
According apt Professor Temps, "DNA achieves its tall degree of photostability through its complex double-helix framework. The interactions among bases that are stacked an on another within a DNA strand, and the hydrogen bonds between the base couples of the 2 complementary unattached strands in the double-helix activity key roles. Through the another interactions that we have observed the DNA doings in a large part as its own sun-protection".
Nina Schwalb investigated many different base combinations in synthetically-produced DNA molecules. Using a femtosecond pulsed laser spectroscope,[link widoczny dla zalogowanych], she measured the characteristic energy release for every combination. She was able to weigh the time for which the molecules continued to fluoresce, and accordingly how long they cached the laser energy. She found that fjust aboutme base combinations these fluorescence ��lifetimes�� were only about 100 femtoseconds,[link widoczny dla zalogowanych], whereas for others they were up to a thousand times longer. A femtosecond is one millionth of a billionth of a second.
Commenting on the conclusions from her research, Nina Schwalb says: ��We have investigated the photophysical properties and have found that different base medleys have widely different fluorescence lifetimes. This could guide to the development of a current diagnostic method whereby laser laser could be accustomed to directly recognise definite genetic sequences without, case in point,[link widoczny dla zalogowanych],[link widoczny dla zalogowanych], having to brand the DNA with pigments as in the method secondhand as yet".
One might likewise envisage linking the photophysical properties to genetic characteristics. When these mechanisms are better understood,[link widoczny dla zalogowanych], it might in the long term transform feasible to repair gene mutations using laser radiation.
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