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Dołączył: 03 Mar 2011
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 Wysłany: Pią 15:53, 11 Mar 2011 Temat postu: nlp jnn lzp skb |
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DMSO, hyaluronidase treatment of docetaxel extravasation injury of rat skin
Compared using analysis of variance (One-WayANOVA) test was used to compare the two groups asked the LSD-t test, variance with TambaneST2 test when missing. 2 Results in each group after injection of docetaxel at different times appeared ill-defined local erythema, edema, erythema color gradually deepened, with clear boundaries around the organization, the majority of rats injected with regional injuries were aggravated, there skin erosion, ulceration, no obvious blisters (Figure 1). DMS0 group, HAase group, DMSO + HAase group, NS coated group, NS injection group, model control group, respectively 10,3,5,10,9,10 injury occurred (Table 1). Injury of rats in each group AUC, and healing time is different, in which the damage HAase group and average the shortest healing time, the model control group, the average healing time was the longest, the difference between the groups was significant (P <O.01 .) The mean AUC and HAase healing time and the model control group, respectively, or NS injection group was significantly different compared, and the mean AUC and DMSo healing time or with the control group were treated with NS group differences were There was a significant (P (0.01), that single drug or HAase treated with local injection of DMSO have extravasation of docetaxel to reduce injury and promote healing effect, but combined DMSO group, the average HAase AUC and injury healing time, compared with 589 · HAase no reduction or shortening, indicating that DMSO and efficacy of combination therapy with single-HAase with HAase was no significant difference. Table 1, the incidence of injury in each group, the average AUC and injury healing time (n-lO, , BIbk1Resukofthev ~ undassessmentafterdifferentadjuvanttreatments (n a 10,-x + s) group n the average number of injured AUC (mmz · d) healing time (d) Note: The model group, (1) P <IO.O1; and treated with NS group, (2) KO.O1; and INS injection group, (3) P <0.01; with the DMSO group, (4) P <0.013 for the discussion of semi-synthetic docetaxel purple fir drugs is cell cycle specific drugs and specific role in M phase cells, by inhibiting cell division, to anti-tumor purposes. the drug treatment of ovarian cancer, breast cancer, non-small cell lung cancer [2 and so have made satisfactory efficacy, clinical application more widely, but can cause leakage into the extravascular tissue injury or necrosis. observed in this study of docetaxel extravasation slow tissue repair after injury. 1, only swelling after injury, the majority of erosion occurs in rats within 1 week, ulcers, the whole injury was not observed blisters gradually damage repair 3 to 4 weeks, no long-term healing of ulcers. relative anthracycline, Changchun Bases, docetaxel extravasation tissue damage due to a lesser extent, which foreign reports docetaxel extravasation symptoms consistent l_3]. docetaxel extravasation injury is no generally accepted method of treatment, there are case reports of foreign E ~] DMSO treated with ease docetaxel extravasation in skin after injury. is a free radical scavenger, its anti-inflammatory, antibacterial, and promote wound healing, and the organization has a strong penetrating power, can eliminate free radicals and reduce the toxicity of the skin after topical rapid absorption, can reduce or prevent a variety of chemotherapeutic drugs extravasation injury]. Laboratory of Applied DMSO frozen cells, clinical application of DMSo was extravasation injury prevention and control of certain anticancer drugs, such as anthracyclines [s], purple fir alkanes [1], but its real effectiveness is still controversial [c;]. The results suggest that single-coated with DMS0 was promoted docetaxel extravasation injury healing. HAase is mucopolysaccharide enzyme, It enables cells in the proteoglycan matrix (hyaluronic acid) hydrolysis and reduce the viscosity of temporary and promote the proliferation of drugs in tissue penetration, and enhance the absorption of the drug organization and reduce the leakage of drug concentrations in the organization, for the prevention and treatment of drug extravasation injury with good results. This study demonstrates that local injection of HAase can significantly reduce the damage, shorten healing time, with good control effect, but DMSo the efficacy of combined treatment with HAase was not better than single HAase. experiments showed that the local treated with DMSO alone, HAase have a certain effect of local injection of a single local injection of HAase efficacy with the best. but because of the limitations of animal experiments, small sample size
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